Testing for IC Root Causes
The following is a summary of various scientific tests that can help reveal root causes and guide you on a healing plan specific to your unique situation.
We're all different so what works for one person may not work for another. We've been through this and understand what you are going through. Our goal is make this information readily available so you can spend more of your time focusing on your recovery.
Please consult with a qualified physician or practitioner to discuss these options.
We hope you find this information helpful and please know that you are not alone. We are here to help!
Comprehensive Urine Culture
Same as sample that is collected and sent to lab for culture over 2-3 days but
lab report will show all levels of possible bacteria, even low Colony Forming Units (CFUs).
Best to do a first or second morning urine sample so that urine is more concentrated.
LabCorp has this option. Code is: 8086 Urine Culture, Comprehensive
We recommend to request this enhanced reporting of the same test to show all levels of found bacteria. Without this add-on request, the report will likely only show bacteria with high concentration, as measured by colony forming units (CFUs). That is, only bacteria with above a certain threshold will be deemed infection level. Ideally you would want the full report so you can work with your doctor if symptoms persist and low level of bacteria CFUs are found.
Most labs use a standard of a measure of bacteria greater than 100,000 colony forming units (CFU)/mL to indicate an infection. It is possible that lower CFUs may indicate an infection, especially if symptoms persist. We recommend discussing the findings with your doctor.
PCR & Next Generation Sequencing (NGS) DNA Tests
MicroGenDx
Use of DNA sequencing to detect pathogens such as bacteria, fungi, candida, and others at the molecular level that standard urine cultures may have missed. This testing can possibly identify bio-film infections. Many physicians and practitioners suggest both urine and vaginal testing since one can affect the other. For men, it is a good idea to test semen as well for possible pathogens.
Level 1: PCR test results are usually available within 24 hours.
Level 2: Next Generation Sequencing (NGS) results are usually available within 7 days.
Level 2 may still show pathogens even if Level 1 is negative.
Note: List of medication options are suggested based on medical literature and not an actual susceptibility.
Test results are sent directly to the physician or practitioner requesting the test, but you can also have MicroGen email the results directly to you by signing their HIPPA form (call them for details: 1-855-208-0019).
MicroGenDX also has the option to do a Vaginal culture, which can be helpful in identifying imbalances that may be contributing to symptoms and infections. You will have to ask MicroGen to send swabs for this test. Make sure your physician/practitioner fills in the correct codes on the requisition. Results are provided as Level 1 (PCR Testing) and Level 2 (NGS).
MyUTI Test
A modern & personalized approach to testing and treatment for bladder infections.
How It Works: Order test directly from MyUTI, seamless and cash based access to advanced testing. The MyUTI kit arrives at your doorstep for convenient home collection. Ship your sample overnight to the CLIA certified lab and the following day receive your results in your personal MyUTI dashboard. Download and share MyUTI test results with your clinician for treatment, or be connected to a specialist in the MyUTI network.
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Targeted - Identify which antibiotics research has shown to be most effective.
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Comprehensive - Test for the top 12 UTI symptom causing bacteria & pathogens.
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Discreet - Simple home collection delivered to your doorstep.
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Fast - Results within a day for immediate treatment.
CirrusDx
Test that identifies and quantifies infectious bacteria and the antibiotics they’re susceptible to: UTIP™ and polyMIC™ help ensure patients get the right diagnosis and prescription, right from the start. In a single day.
Pathnostics
"Guidance UTI" is a rapid molecular test utilizing advanced technologies that identify pathogens commonly associated with recurrent or persistent urinary tract infections, interstitial cystitis or prostatitis. This test includes a susceptibility analysis on the results to help determine the best antibiotic option.
These tests are becoming more readily available and can be ordered by your physician or practitioner.
Additional Testing
Additional testing to identify possible imbalances include (but are not limited to):
Pelvic Ultrasound
This non-invasive test can be helpful to see if there are any other possible causes for your symptoms, such as ovarian cysts or fibroids.
Post-Void Residual Urine Test
This test checks to see if you are retaining any urine. Can be done at the same time as pelvic ultrasound.
Pelvic Floor Dysfunction (PFD): a trained Physical Therapist can help tremendously if symptoms are caused by PFD.
Full Blood Work including: CBC, Kidney Function, ANA, and HNK1 CD57.
Thyroid: there is a direct connection between the thyroid and bladder.
Dutch Dried Urine Test / Hormones: for example, low estrogen is known to cause bladder issues. Dutch Dried Urine test is a good option to determine any imbalance. Learn More About Dutch Test
Organic Acids Test (OAT) by Great Plains Laboratory, Inc.: The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with 76 markers. It can provide an accurate evaluation of intestinal yeast and bacteria. Abnormally high levels of these microorganisms can cause or worsen certain health conditions. Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and oxalates. Learn More About OAT
Vitamin deficiencies: Vitamin D3 being a common factor with bladder health and immunity.
Lyme Disease and Co-Infections: These pathogens commonly cause bladder issues.
Gene mutations such as MTHFR (methylenetetrahydrofolate reductase -- don't worry we can't pronounce it either). It's important to test for MTHFR a1298c and c677t gene mutations since many people with bladder issues have this gene mutation, so it's good to know if this needs to be addressed.
Please note if taking a B12 vitamin please ensure it is the Methylated form, "Methylcobalamin" and not the synthetic form, "Cyanocobalamin." The cyanocobalamin version of B12 is made from cyanide, which is not ideal and for those with MTHFR gene mutations. Watch out for a blog on the MTHFR / bladder connection!
Systemic issues such as Candida: Natural cleanses and practitioner-led protocols can help the body recover.
Small Intestinal Bacterial Overgrowth (SIBO): Genova has a popular test that can be discussed with your doctor.
Interference Fields / Previous Surgeries or Injuries: Scar tissue or injury can affect the meridians and blood flow to certain areas of the body so it's helpful to get these checked. Mud packing can help clear these interference fields to promote healing and strengthen the area. A C-Section is a good example of a surgery that affects circulation and can be addressed. Also, any injury to the spine can directly affect the bladder.
Comprehensive Stool Analysis: Tests such as Doctor's Data or Genova Diagnostics can be ordered by your doctor to detect imbalances, possible pathogens and parasites . For example, low elastase levels (enzyme produced by special tissue in the pancreas) can contribute to painful symptoms as well as Yeast and/or bacterial imbalances. Make sure analysis report includes a list of herbs/supplements and medicine that any found pathogens are susceptible to.